Paclitaxel synthetic studies. A Diels–Alder approach to the A-ring

Santiago Carballares; Donald Craig; Charlotte A. L. Lane; A. Roderick MacKenzie; William P. Mitchell; Anthony Wood

doi:10.1039/B005533F

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Paclitaxel synthetic studies. A Diels–Alder approach to the A-ringExperimental details for 4, 13, 16, 17, 19–21 are available as supplementary data. For direct electronic access see http://www.rsc.org/suppdata/cc/b0/b005533f/

Santiago Carballares,^a Donald Craig,*^a Charlotte A. L. Lane,^a A. Roderick MacKenzie,^b William P. Mitchell^a and Anthony Wood^b

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* Corresponding authors

^a Centre for Chemical Synthesis, Department of Chemistry, Imperial College of Science, Technology and Medicine, London, UK
E-mail: d.craig@ic.ac.uk

^b Pfizer Central Research, Kent, Sandwich, UK

Abstract

Highly substituted cyclohexenes corresponding to the A-ring of the anti-cancer diterpene natural product paclitaxel are synthesised using a Diels–Alder reaction and decarboxylative elimination as the key steps.

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Supplementary files

Experimental details for 4, 13, 16, 17, 19– 21 DOC (48K)

Article information

DOI: https://doi.org/10.1039/B005533F
Article type: Communication
Submitted: 11 Jul 2000
Accepted: 04 Aug 2000
First published: 29 Aug 2000

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Chem. Commun., 2000, 1767-1768

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Paclitaxel synthetic studies. A Diels–Alder approach to the A-ring

S. Carballares, D. Craig, C. A. L. Lane, A. R. MacKenzie, W. P. Mitchell and A. Wood, Chem. Commun., 2000, 1767 DOI: 10.1039/B005533F

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Chemical Communications

Paclitaxel synthetic studies. A Diels–Alder approach to the A-ringExperimental details for 4, 13, 16, 17, 19–21 are available as supplementary data. For direct electronic access see http://www.rsc.org/suppdata/cc/b0/b005533f/

Abstract

Supplementary files

Article information

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Paclitaxel synthetic studies. A Diels–Alder approach to the A-ring

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