Issue 1, 2001
From the journal:

Chemical Communications

Dynamic kinetic resolution of tert-butyl 4-methyl-3,5-dioxohexanoate through enzymatic reduction

Aiguo Ji,a   Michael Wolberg,a   Werner Hummel,c   Christian Wandreya  and  Michael Müller*a  

* Corresponding authors

a Institut für Biotechnologie 2, Forschungszentrum Jülich GmbH, Jülich, Germany.
E-mail: E-mail: mi.mueller@fz-juelich.de

b Department of Pharmacy, Shandong Medical University, Jinan, China

c Institut für Enzymtechnologie der Heinrich-Heine Universität Düsseldorf im Forschungszentrum Jülich GmbH, Jülich, Germany

Abstract

An entirely new method for the dynamic kinetic resolution of a racemic, 2-methyl substituted, unsymmetrical 1,3-diketone via enzymatic reduction to give an enantiomerically pure compound is introduced.

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Article information

DOI
https://doi.org/10.1039/B007448I
Article type
Communication
Submitted
08 Sep 2000
Accepted
15 Nov 2000
First published
14 Dec 2000

Chem. Commun., 2001, 57-58

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Dynamic kinetic resolution of tert-butyl 4-methyl-3,5-dioxohexanoate through enzymatic reduction

A. Ji, M. Wolberg, W. Hummel, C. Wandrey and M. Müller, Chem. Commun., 2001, 57 DOI: 10.1039/B007448I

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