Issue 24, 2001

Asymmetric routes in the reaction of cyclic keteneortho ester with aldehydes involving the use of chiral Lewis acid

Abstract

Enantio- and diastereoselective synthesis of threo 2 and erythro 3 was accomplished by the conversion of 1 with aldehydes promoted by chiral borane 10; enantioselctivities range from 45–95% ee, while diastereoselectivities vary from 4.3–49∶1 with 8 different aldehydes.

Graphical abstract: Asymmetric routes in the reaction of cyclic ketene ortho ester with aldehydes involving the use of chiral Lewis acid

Article information

Article type
Communication
Submitted
16 Aug 2001
Accepted
06 Nov 2001
First published
26 Nov 2001

Chem. Commun., 2001, 2698-2699

Asymmetric routes in the reaction of cyclic ketene ortho ester with aldehydes involving the use of chiral Lewis acid

C. Yu, J. Lee, K. Chun, I. Choi and S. Kang, Chem. Commun., 2001, 2698 DOI: 10.1039/B107454G

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