Issue 14, 2002
From the journal:

Chemical Communications

Probing the effect of a 3′-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug design†

Andrew P. G. Beevers,a   Kevin J. Fettes,b   Ian A. O’Neil,b   Stanley M. Roberts,b   John R. P. Arnold,c   Richard Cosstickb  and  Julie Fisher*a  

* Corresponding authors

a Department of Chemistry, University of Leeds, Leeds, UK
E-mail: J.Fisher@chem.leeds.ac.uk
Fax: 44 (0) 113 343 6565
Tel: 44 (0) 113 343 6577

b Department of Chemistry, University of Liverpool, Liverpool, UK

c YCR Laboratory of Drug Design, University of Bradford, Bradford, UK

Abstract

The effects of a single 3′-S-phosphorothiolate link in the DNA strand of a DNA:RNA dodecamer duplex is described; the sulfur induces a conformational shift in the (attached) sugar pucker, as shown by 1H NMR studies, and increases the thermal stability of the duplex compared to the non-modified system.

Graphical abstract: Probing the effect of a 3′-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug design

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B203582K
Article type
Communication
Submitted
15 Apr 2002
Accepted
16 May 2002
First published
06 Jun 2002

Chem. Commun., 2002, 1458-1459

Permissions

Request permissions

Probing the effect of a 3′-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug design

A. P. G. Beevers, K. J. Fettes, I. A. O’Neil, S. M. Roberts, J. R. P. Arnold, R. Cosstick and J. Fisher, Chem. Commun., 2002, 1458 DOI: 10.1039/B203582K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements