A hybrid temperature-responsive hydroxyapatite–poly(N-isopropylacrylamide) (HAP–PNIPAAm) gel has been synthesized by the interpenetration of PNIPAAm into a sintered HAP disk through a radical-initiated polymerization of NIPAAm monomers under N2 atmosphere, and shows sustained positive thermo-responsive drug release profile over a month at PBS buffer.
Y. Shin, J. Liu, J. H. Chang and G. J. Exarhos, Chem. Commun., 2002, 1718 DOI: 10.1039/B204703A
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