Issue 14, 2003
From the journal:

Chemical Communications

Gold(iii) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells†

Chi-Ming Che,*a   Raymond Wai-Yin Sun,a   Wing-Yiu Yu,a   Chi-Bun Ko,a   Nianyong Zhua  and  Hongzhe Sun*a  

* Corresponding authors

a Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: cmche@hku.hk
Fax: +(852)2857-1586

Abstract

A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.

Graphical abstract: Gold(iii) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

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Article information

DOI
https://doi.org/10.1039/B303294A
Article type
Communication
Submitted
26 Mar 2003
Accepted
21 May 2003
First published
16 Jun 2003

Chem. Commun., 2003, 1718-1719

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Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

C. Che, R. W. Sun, W. Yu, C. Ko, N. Zhu and H. Sun, Chem. Commun., 2003, 1718 DOI: 10.1039/B303294A

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