Issue 21, 2003

Production of vancomycin aglycone conjugated to a peptide carrier domain derived from a biosynthetic non-ribosomal peptide synthetase

Abstract

A method for attaching the vancomycin aglycone to a peptide carrier domain (PCD) is reported which involves reacting the apo-PCD produced in Escherichia coli with vancomycin aglycone-coenzyme A thioester, catalyzed by the phosphopantetheinyl transferase Sfp from Bacillus subtilis.

Graphical abstract: Production of vancomycin aglycone conjugated to a peptide carrier domain derived from a biosynthetic non-ribosomal peptide synthetase

Article information

Article type
Communication
Submitted
18 Jul 2003
Accepted
01 Sep 2003
First published
02 Oct 2003

Chem. Commun., 2003, 2718-2719

Production of vancomycin aglycone conjugated to a peptide carrier domain derived from a biosynthetic non-ribosomal peptide synthetase

F. Vitali, K. Zerbe and J. A. Robinson, Chem. Commun., 2003, 2718 DOI: 10.1039/B308247D

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