Issue 4, 2004
From the journal:

Chemical Communications

Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier†‡

Teruaki Hasegawa,a   Mariko Umeda,a   Takahiro Matsumoto,a   Munenori Numata,a   Masami Mizu,b   Kazuya Koumoto,b   Kazuo Sakuraib  and  Seiji Shinkai*a  

* Corresponding authors

a Department of Chemistry and Biotechnology, Graduate School of Engineering, Kyushu University, Hakozaki, 6-10-1, Higashi-ku, Fukuoka 812-8581, Japan

b Department of Chemical Processes and Environments, Faculty of Environmental Engineering, The University of Kitakyushu, Hibikino, 1-1, Wakamatsu-ku, Fukuoka 808-0135, Japan

Abstract

A schizophyllan (β-1,3-glucan) derivative carrying lactose-appendages prepared by reductive amination can form stable macromolecular complexes with polynucleotides, shows excellent affinity with a lactose-binding lectin, and effectively mediates gene transfection into hepatocytes.

Graphical abstract: Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

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Article information

DOI
https://doi.org/10.1039/B313426A
Article type
Communication
Submitted
23 Oct 2003
Accepted
17 Dec 2003
First published
26 Jan 2004

Chem. Commun., 2004, 382-383

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Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

T. Hasegawa, M. Umeda, T. Matsumoto, M. Numata, M. Mizu, K. Koumoto, K. Sakurai and S. Shinkai, Chem. Commun., 2004, 382 DOI: 10.1039/B313426A

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