Issue 2, 2005
From the journal:

Chemical Communications

Notable deuterium effect on the electron transfer rate of myoglobin

Yasuhiro Mie,*a   Chiho Yamada,b   Tadayuki Uno,c   Saburo Neya,d   Fumio Mizutani,a   Katsuhiko Nishiyamab  and  Isao Taniguchib  

* Corresponding authors

a National Institute of Advanced Industrial Science and Technology, 2-17-2-1, Tsukisamu-higashi, Sapporo, Japan
E-mail: yasuhiro.mie@aist.go.jp
Tel: +81-11-857-8913

b Department of Applied Chemistry and Biochemistry, Kumamoto University, Japan

c Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan

d Graduate School of Pharmaceutical Sciences, Chiba University, Japan

Abstract

The electron transfer reaction of wild-type myoglobin at an electrode was significantly facilitated in a D2O buffer as compared with that in an H2O buffer, with k0′H2O/k0′D2O = 0.13, while a minimal deuterium kinetic isotope effect on the myoglobin with modification at distal histidine (His-64) was observed.

Graphical abstract: Notable deuterium effect on the electron transfer rate of myoglobin

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Article information

DOI
https://doi.org/10.1039/B413100B
Article type
Communication
Submitted
26 Aug 2004
Accepted
22 Oct 2004
First published
17 Nov 2004

Chem. Commun., 2005, 250-252

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Notable deuterium effect on the electron transfer rate of myoglobin

Y. Mie, C. Yamada, T. Uno, S. Neya, F. Mizutani, K. Nishiyama and I. Taniguchi, Chem. Commun., 2005, 250 DOI: 10.1039/B413100B

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