Issue 4, 2005
From the journal:

Chemical Communications

Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates†

David A. Fulton,a   Mark O'Halloran,a   David Parker,*a   Kanthi Senanayake,a   Mauro Bottab  and  Silvio Aimec  

* Corresponding authors

a Department of Chemistry, University of Durham, South Road, Durham, UK
E-mail: david.parker@durham.ac.uk

b Dipartimento di Scienze dell' Ambiente e delle Vita, Università del Piemonte Orientale ‘Amedeo Avogadro’, Spalto Morengo 33, Alessandria, Italy

c Dipartimento di Chimica IFM, Universita degli Studi di Torino, 7 via P. Giuria, Torino, Italy

Abstract

Enhancement of the relaxivities of Gd-based MRI contrast agents is achieved by placing the metal ion at the barycentre of the molecular complex in order to improve motional coupling.

Graphical abstract: Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates

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Article information

DOI
https://doi.org/10.1039/B413536A
Article type
Communication
Submitted
03 Sep 2004
Accepted
08 Oct 2004
First published
17 Dec 2004

Chem. Commun., 2005, 474-476

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Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates

D. A. Fulton, M. O'Halloran, D. Parker, K. Senanayake, M. Botta and S. Aime, Chem. Commun., 2005, 474 DOI: 10.1039/B413536A

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