Issue 4, 2005

A new approach to construct full-length glycosylphosphatidylinositols of parasitic protozoa and [4-deoxy-Man-III]-GPI analogues

Abstract

A new [2 + 2 + 2] approach to construct GPI molecules through the efficient synthesis of glucosamine-inositol and tetramannose intermediates led to a total synthesis of a GPI-anchor of Trypanosoma cruzi, and also afforded a key intermediate for the synthesis of valuable [4-deoxy-Man-III]-GPI analogues.

Graphical abstract: A new approach to construct full-length glycosylphosphatidylinositols of parasitic protozoa and [4-deoxy-Man-III]-GPI analogues

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
17 Sep 2004
Accepted
13 Oct 2004
First published
02 Dec 2004

Chem. Commun., 2005, 519-521

A new approach to construct full-length glycosylphosphatidylinositols of parasitic protozoa and [4-deoxy-Man-III]-GPI analogues

A. Ali, D. C. Gowda and R. A. Vishwakarma, Chem. Commun., 2005, 519 DOI: 10.1039/B414119A

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