Fluorescence studies of the intra-cellular distribution of zinc bis(thiosemicarbazone) complexes in human cancer cells

Andrew R. Cowley; Jason Davis; Jonathan R. Dilworth; Paul S. Donnelly; Rachel Dobson; Adrian Nightingale; Josephine M. Peach; Ben Shore; David Kerr; Len Seymour

doi:10.1039/B417206J

Fluorescence studies of the intra-cellular distribution of zinc bis(thiosemicarbazone) complexes in human cancer cells†

Andrew R. Cowley,^a Jason Davis,^a Jonathan R. Dilworth,*^a Paul S. Donnelly,^a Rachel Dobson,^a Adrian Nightingale,^a Josephine M. Peach,^a Ben Shore,^a David Kerr^b and Len Seymour^b

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^a Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK
E-mail: jon.dilworth@chemistry.oxford.ac.uk

^b Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford, UK

Abstract

The uptake of zinc bis(thiosemicarbazone) complexes in human cancer cells has been studied by fluorescence microscopy and the cellular distribution established, including the degree of uptake in the nucleus.

Chemical Communications

Fluorescence studies of the intra-cellular distribution of zinc bis(thiosemicarbazone) complexes in human cancer cells†

Abstract

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Fluorescence studies of the intra-cellular distribution of zinc bis(thiosemicarbazone) complexes in human cancer cells

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