Synthesis of C2-chiral bifunctionalised spin labels and their application to troponin C

Shunsuke Chatani; Motoyoshi Nakamura; Hidenobu Akahane; Naoki Kohyama; Masayasu Taki; Toshiaki Arata; Yukio Yamamoto

doi:10.1039/B418016J

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Synthesis of C₂-chiral bifunctionalised spin labels and their application to troponin C†

Shunsuke Chatani,^a Motoyoshi Nakamura,^b Hidenobu Akahane,^a Naoki Kohyama,^a Masayasu Taki,^a Toshiaki Arata^b and Yukio Yamamoto*^a

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* Corresponding authors

^a Graduate School of Human & Environmental Studies, Kyoto University, Sakyo-ku, Yoshida, Kyoto 606-8501, Japan
E-mail: yukio@fischer.jinkan.kyoto-u.ac.jp
Fax: +81 75 753 6833
Tel: +81 75 753 6833

^b Department of Biology, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043, Japan
E-mail: arata@bio.sci.osaka-u.ac.jp
Fax: +81 6 6850 5441
Tel: +81 6 6850 5427

Abstract

An enantiomeric pair of C₂-chiral bifunctionalised spin labels having a pyrrolidine nitroxide moiety, whose configurations were determined by X-ray crystal diffraction analysis, was prepared and applied to troponin C whose binding mode of double disulfide linkage was proved by EPR spectroscopy.

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Article information

DOI: https://doi.org/10.1039/B418016J
Article type: Communication
Submitted: 30 Nov 2004
Accepted: 28 Jan 2005
First published: 11 Feb 2005

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Chem. Commun., 2005, 1880-1882

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Synthesis of C₂-chiral bifunctionalised spin labels and their application to troponin C

S. Chatani, M. Nakamura, H. Akahane, N. Kohyama, M. Taki, T. Arata and Y. Yamamoto, Chem. Commun., 2005, 1880 DOI: 10.1039/B418016J

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Chemical Communications