Issue 6, 2006
From the journal:

Chemical Communications

Rapid generation of molecular complexity using “hybrid” multi-component reactions (MCRs): application to the synthesis of α-amino nitriles and 1,2-diamines†

Jason J. Shiers,a   Guy J. Clarkson,a   Michael Shipman*a  and  Jerome F. Hayesb  

* Corresponding authors

a Department of Chemistry, University of Warwick, Gibbert Hill Road, Coventry, UK
E-mail: m.shipman@warwick.ac.uk
Fax: +44 24765 24429
Tel: +44 24765 23186

b GlaxoSmithKline, Old Powder Mills, Tonbridge, UK

Abstract

Methyleneaziridines can be converted into a wide range of 1,2-diamines and 2-cyanopiperidines in a single operation with the formation of three intermolecular carbon–carbon bonds using a “hybrid” MCR.

Graphical abstract: Rapid generation of molecular complexity using “hybrid” multi-component reactions (MCRs): application to the synthesis of α-amino nitriles and 1,2-diamines

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Article information

DOI
https://doi.org/10.1039/B516192D
Article type
Communication
Submitted
15 Nov 2005
Accepted
09 Dec 2005
First published
06 Jan 2006

Chem. Commun., 2006, 649-651

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Rapid generation of molecular complexity using “hybrid” multi-component reactions (MCRs): application to the synthesis of α-amino nitriles and 1,2-diamines

J. J. Shiers, G. J. Clarkson, M. Shipman and J. F. Hayes, Chem. Commun., 2006, 649 DOI: 10.1039/B516192D

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