Issue 46, 2006
From the journal:

Chemical Communications

A new consecutive three-component oxazole synthesis by an amidation–coupling–cycloisomerization (ACCI) sequence†

Eugen Merkula  and  Thomas J. J. Müller*a  

* Corresponding authors

a Organisch-Chemisches Institut der Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, Heidelberg, Germany
E-mail: Thomas.J.J.Mueller@oci.uni-heidelberg.de
Fax: +49(0)6221546579
Tel: +49(0)6221546207

Abstract

A novel consecutive three-component synthesis of 1-(hetero)aryl-2-(2-(hetero)aryl-oxazol-5-yl) ethanones starting from propargyl amine and acid chlorides, both for amidation and cross-coupling, is based upon an amidation–coupling–cycloisomerization (ACCI) sequence.

Graphical abstract: A new consecutive three-component oxazole synthesis by an amidation–coupling–cycloisomerization (ACCI) sequence

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Article information

DOI
https://doi.org/10.1039/B610839C
Article type
Communication
Submitted
27 Jul 2006
Accepted
12 Sep 2006
First published
29 Sep 2006

Chem. Commun., 2006, 4817-4819

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A new consecutive three-component oxazole synthesis by an amidation–coupling–cycloisomerization (ACCI) sequence

E. Merkul and T. J. J. Müller, Chem. Commun., 2006, 4817 DOI: 10.1039/B610839C

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