Issue 46, 2007
From the journal:

Chemical Communications

Scaffolded amino acids as a close structural mimic of type-3 copper binding sites†

H. Bauke Albada,a   Fouad Soulimani,b   Bert M. Weckhuysenb  and  Rob M. J. Liskamp*a  

* Corresponding authors

a Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80082, Utrecht, The Netherlands
E-mail: r.m.j.liskamp@uu.nl
Web: http://www.pharm.uu.nl/medchem
Fax: +31 30-2536655
Tel: +31 30-2537396

b Inorganic Chemistry and Catalysis group, Department of Chemistry, Faculty of Science, Utrecht University, Sorbonnelaan 16, Utrecht, The Netherlands.

Abstract

We report the use of triazacyclophane (TAC)-scaffolded amino acids as a structural mimic for 3-histidine metal-binding sites in metalloproteins, especially for the mimicry of type-3 copper binding sites as are present in hemocyanin, tyrosinase and catechol oxidase.

Graphical abstract: Scaffolded amino acids as a close structural mimic of type-3 copper binding sites

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Article information

DOI
https://doi.org/10.1039/B709400K
Article type
Communication
Submitted
20 Jun 2007
Accepted
18 Oct 2007
First published
02 Nov 2007

Chem. Commun., 2007, 4895-4897

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Scaffolded amino acids as a close structural mimic of type-3 copper binding sites

H. B. Albada, F. Soulimani, B. M. Weckhuysen and R. M. J. Liskamp, Chem. Commun., 2007, 4895 DOI: 10.1039/B709400K

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