Thermodynamic double-mutant cycles and triple-mutant boxes are widely employed for the experimental quantification of non-covalent interactions and cooperative effects in proteins. This review describes the application of these powerful methodologies to the study of non-covalent interactions in synthetic systems.
S. L. Cockroft and C. A. Hunter, Chem. Soc. Rev., 2007, 36, 172 DOI: 10.1039/B603842P
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