Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics

Abstract

Covering: bacterial genome sequences to 2005 and post-genomic literature to June 2006

A total of 223 complete bacterial genomes are analyzed, with 281 citations, for the presence of genes encoding modular polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS). We report on the distribution of these systems in different bacterial taxa and, whenever known, the metabolites they synthesize. We also highlight, in the different bacterial lineages, the PKS and NRPS genes and, whenever known, the corresponding products.