Novel approach for the synthesis of Fe3O4@TiO2 core–shell microspheres and their application to the highly specific capture of phosphopeptides for MALDI-TOF MS analysis

Yan Li; Jinsong Wu; Dawei Qi; Xiuqing Xu; Chunhui Deng; Pengyuan Yang; Xiangmin Zhang

doi:10.1039/B716055K

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Novel approach for the synthesis of Fe₃O₄@TiO₂ core–shell microspheres and their application to the highly specific capture of phosphopeptides for MALDI-TOF MS analysis†

Yan Li,‡^a Jinsong Wu,‡^b Dawei Qi,^a Xiuqing Xu,^a Chunhui Deng,*^a Pengyuan Yang^a and Xiangmin Zhang*^a

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* Corresponding authors

^a Department of Chemistry, Fudan University, China
E-mail: chdeng@fudan.edu.cn, xmzhang@fudan.edu.cn
Fax: +86 21-6564 1740

^b Shanghai Neurosurgical Center, Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, China

Abstract

A novel approach is proposed to synthesize Fe₃O₄@TiO₂ microspheres with a well-defined core–shell structure, and the synthesized Fe₃O₄@TiO₂ core–shell microspheres were successfully applied for the simple and fast enrichment of phosphopeptides via direct MALDI-TOF mass spectrometry analysis.

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Supplementary files

Experimental details, FTIR spectra, TEM images of various metal oxide coated magnetite microspheres, and detailed information on the enrichment of β-casein and casein PDF (5444K)

Article information

DOI: https://doi.org/10.1039/B716055K
Article type: Communication
Submitted: 17 Oct 2007
Accepted: 12 Nov 2007
First published: 20 Nov 2007

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Chem. Commun., 2008, 564-566

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Novel approach for the synthesis of Fe₃O₄@TiO₂ core–shell microspheres and their application to the highly specific capture of phosphopeptides for MALDI-TOF MS analysis

Y. Li, J. Wu, D. Qi, X. Xu, C. Deng, P. Yang and X. Zhang, Chem. Commun., 2008, 564 DOI: 10.1039/B716055K

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