Issue 11, 2008
From the journal:

Soft Matter

Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles†

Rameshwer Shukla,*a   Elliott Hill,b   Xiangyang Shi,a   Jinkoo Kim,b   Maria C. Muniz,a   Kai Sunc  and  James R. Baker,  Jr.*a  

* Corresponding authors

a Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Abor, USA

b Department of Biologic and Materials Sciences, University of Michigan, Ann Abor, USA

c Electron Microbeam Analysis Laboratory, University of Michigan, Ann Arbor, USA

Abstract

Monodisperse dendrimer-entrapped gold nanoparticles (diameter = 3.0 nm) were prepared using G5 poly(amidoamine) (PAMAM) dendrimer functionalized with fluorescein isothiocyanate (FI) and Arg-Gly-Asp (RGD) peptide as template; in vitro targeting efficacy to integrin receptor expressing cells was confirmed by flow cytometry, confocal microscopy, and ICP-MS.

Graphical abstract: Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles

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Article information

DOI
https://doi.org/10.1039/B810885D
Article type
Communication
Submitted
27 Jun 2008
Accepted
12 Aug 2008
First published
27 Aug 2008

Soft Matter, 2008,4, 2160-2163

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Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles

R. Shukla, E. Hill, X. Shi, J. Kim, M. C. Muniz, K. Sun and J. R. Baker, Soft Matter, 2008, 4, 2160 DOI: 10.1039/B810885D

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