A lysine walk to high relaxivity collagen-targeted MRI contrast agents

Peter Caravan; Biplab Das; Qing Deng; Stéphane Dumas; Vincent Jacques; Steffi K. Koerner; Andrew Kolodziej; Richard J. Looby; Wei-Chuan Sun; Zhaoda Zhang

doi:10.1039/B819098D

A lysine walk to high relaxivity collagen-targeted MRI contrast agents†

Peter Caravan,*^a Biplab Das,^b Qing Deng,^b Stéphane Dumas,^b Vincent Jacques,^b Steffi K. Koerner,^b Andrew Kolodziej,^b Richard J. Looby,^b Wei-Chuan Sun^b and Zhaoda Zhang^b

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^a A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA, USA
E-mail: caravan@nmr.mgh.harvard.edu
Fax: +1 (0)617 726 7422

^b Epix Pharmaceuticals, 4 Maguire Road, Lexington, MA, USA

Abstract

A strategy for preparing peptide-based magnetic resonance contrast agents with multiple gadolinium chelates is described.

Chemical Communications

A lysine walk to high relaxivity collagen-targeted MRI contrast agents†

Abstract

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A lysine walk to high relaxivity collagen-targeted MRI contrast agents

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