Issue 48, 2009

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

Abstract

Quadruplex RNAs are less well understood than their DNA counterparts, yet of potentially high biological relevance. The interactions of several quadruplex-binding ligands with telomeric RNA quadruplexes are reported and compared with their binding to the analogous DNA quadruplexes.

Graphical abstract: Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

Supplementary files

Article information

Article type
Communication
Submitted
29 Jan 2009
Accepted
24 Oct 2009
First published
13 Nov 2009

Chem. Commun., 2009, 7482-7484

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

G. Collie, A. P. Reszka, S. M. Haider, V. Gabelica, G. N. Parkinson and S. Neidle, Chem. Commun., 2009, 7482 DOI: 10.1039/B901889A

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