Issue 26, 2009
From the journal:

Chemical Communications

Palladium-catalysed enantioselective α-hydroxylation of β-ketoesters†

Alexander M. R. Smith,a   Denis Billenb  and  King Kuok (Mimi) Hii*a  

* Corresponding authors

a Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, UK
E-mail: mimi.hii@imperial.ac.uk
Fax: +44-(0)20-7594-5804

b Pfizer Animal Health, 333 Portage Street, Kalamazoo, USA

Abstract

Highly enantioselective α-hydroxylation of cyclic and acyclic 1,3-ketoesters can be achieved with up to 98% ee using a dicationic palladium(II) catalyst and dimethyldioxirane as oxidant.

Graphical abstract: Palladium-catalysed enantioselective α-hydroxylation of β-ketoesters

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B907151B
Article type
Communication
Submitted
08 Apr 2009
Accepted
01 May 2009
First published
22 May 2009

Chem. Commun., 2009, 3925-3927

Permissions

Request permissions

Palladium-catalysed enantioselective α-hydroxylation of β-ketoesters

A. M. R. Smith, D. Billen and K. K. (. Hii, Chem. Commun., 2009, 3925 DOI: 10.1039/B907151B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements