Issue 28, 2009
From the journal:

Chemical Communications

Mismatch DNA-specific enzymatic cleavage employed in a new method for the electrochemical detection of genetic mutations†

Byoung Yeon Won,a   Sung Chul Shin,a   Won-young Chung,a   Sujeong Shin,a   Dae-Yeon Chob  and  Hyun Gyu Park*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, KAIST, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea
E-mail: hgpark@kaist.ac.kr
Fax: +82 42-350-3910
Tel: +82 42-350-3932

b Clinical Research Institute, Labgenomics Co. Ltd., Doo San Engineering Center 449-795, Seongbok DongYong-In, Gyeonggi, Republic of Korea

Abstract

Utilizing enzymatic mismatched DNA-specific cleavage and electrocatalytic signaling, a new electrochemical method for the detection of DNA mutations was developed and successfully applied to detect various mutations in the BRCA1gene.

Graphical abstract: Mismatch DNA-specific enzymatic cleavage employed in a new method for the electrochemical detection of genetic mutations

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Article information

DOI
https://doi.org/10.1039/B907268C
Article type
Communication
Submitted
09 Apr 2009
Accepted
15 May 2009
First published
09 Jun 2009

Chem. Commun., 2009, 4230-4232

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Mismatch DNA-specific enzymatic cleavage employed in a new method for the electrochemical detection of genetic mutations

B. Y. Won, S. C. Shin, W. Chung, S. Shin, D. Cho and H. G. Park, Chem. Commun., 2009, 4230 DOI: 10.1039/B907268C

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