Issue 29, 2009
From the journal:

Chemical Communications

A DNA-binding Gd chelate for the detection of cell death by MRI†

Elisabeth Garanger,a   Scott A. Hilderbrand,a   Joseph T. Blois,a   David E. Sosnovik,ab   Ralph Weisslederac  and  Lee Josephson*a  

* Corresponding authors

a Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA
E-mail: ljosephson@mgh.harvard.edu
Fax: 1 617 726 5708
Tel: 1 617 726 6478

b Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA

c Center for Systems Biology, Massachusetts General Hospital and the Department of Systems Biology, Harvard Medical School, Boston MA, USA

Abstract

GadoTO, a MR contrast agent for the detection of cell death, consists of a nucleic acid-binding fluorophore attached to a gadolinium chelate.

Graphical abstract: A DNA-binding Gd chelate for the detection of cell death by MRI

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Article information

DOI
https://doi.org/10.1039/B907375B
Article type
Communication
Submitted
14 Apr 2009
Accepted
18 May 2009
First published
12 Jun 2009

Chem. Commun., 2009, 4444-4446

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A DNA-binding Gd chelate for the detection of cell death by MRI

E. Garanger, S. A. Hilderbrand, J. T. Blois, D. E. Sosnovik, R. Weissleder and L. Josephson, Chem. Commun., 2009, 4444 DOI: 10.1039/B907375B

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