Issue 34, 2009
From the journal:

Chemical Communications

Boiling water-catalyzed neutral and selective N-Boc deprotection†

Jia Wang,a   Yan-Liang Lianga  and  Jin Qu*a  

* Corresponding authors

a State key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
E-mail: qujin@nankai.edu.cn
Fax: +86-22-23499254
Tel: +86-22-23499247

Abstract

A general protocol for removing Boc groups from various types of nitrogen is reported and a preliminary investigation of the reaction mechanism indicates that water acts as a dual acid/base catalyst at elevated temperature.

Graphical abstract: Boiling water-catalyzed neutral and selective N-Boc deprotection

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Article information

DOI
https://doi.org/10.1039/B910239F
Article type
Communication
Submitted
26 May 2009
Accepted
08 Jul 2009
First published
31 Jul 2009

Chem. Commun., 2009, 5144-5146

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Boiling water-catalyzed neutral and selective N-Boc deprotection

J. Wang, Y. Liang and J. Qu, Chem. Commun., 2009, 5144 DOI: 10.1039/B910239F

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