Issue 37, 2009

Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles

Abstract

The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.

Graphical abstract: Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles

Supplementary files

Article information

Article type
Communication
Submitted
10 Jun 2009
Accepted
20 Jul 2009
First published
11 Aug 2009

Chem. Commun., 2009, 5541-5542

Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles

V. J. Venditto, K. Allred, C. D. Allred and E. E. Simanek, Chem. Commun., 2009, 5541 DOI: 10.1039/B911353C

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