Issue 37, 2009
From the journal:

Chemical Communications

Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol†

Neil Vasdev,*ab   Jason Chio,c   Erik M. van Oosten,ac   Mark Nitz,c   JoAnne McLaurin,d   Douglass C. Vines,ef   Sylvain Houle,ab   Raymond M. Reillyg  and  Alan A. Wilsonab  

* Corresponding authors

a PET Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, Canada
E-mail: neil.vasdev@camhpet.ca
Fax: +1-416-979-4656
Tel: +1-416-535-8501 ext. 4680

b Department of Psychiatry, University of Toronto, Toronto, ON, Canada

c Department of Chemistry, University of Toronto, Toronto, ON, Canada

d Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada

e STTARR Innovation Centre, Radiation Medicine Program., Princess Margaret Hospital, Toronto, ON, Canada

f Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada

g Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada

Abstract

A novel PET radiotracer, [18F]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 ± 3% uncorrected radiochemical yield within 80 minutes; although this compound revealed low brain penetration it shows promise in rodent tumour models for breast cancer imaging.

Graphical abstract: Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol

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Article information

DOI
https://doi.org/10.1039/B913317H
Article type
Communication
Submitted
06 Jul 2009
Accepted
22 Jul 2009
First published
11 Aug 2009

Chem. Commun., 2009, 5527-5529

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Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol

N. Vasdev, J. Chio, E. M. van Oosten, M. Nitz, J. McLaurin, D. C. Vines, S. Houle, R. M. Reilly and A. A. Wilson, Chem. Commun., 2009, 5527 DOI: 10.1039/B913317H

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