Issue 5, 2009
From the journal:

CrystEngComm

Ziprasidone malate, a new trimorphic salt with improved aqueous solubility†

Anna Portell,a   Rafael Barbas,a   Mercè Font-Bardia,b   Pere Dalmases,c   Rafel Prohens*a  and  Cristina Puigjaner*a  

* Corresponding authors

a Plataforma de Polimorfisme i Calorimetria, Serveis Cientificotècnics, Universitat de Barcelona, Baldiri Reixac, 10, Barcelona, Spain
E-mail: rafel@sct.ub.es, cris@sct.ub.es
Fax: +34 934037206
Tel: +34 934034656

b Unitat de Difracció de Raigs X, Serveis Cientificotècnics, Universitat de Barcelona, Lluís Solé i Sabarís, 1-3, Barcelona, Spain

c Laboratorios Lesvi, Avda. Barcelona, 69, Sant Joan Despí, Spain
E-mail: pdalmase@lesvi.com
Fax: +34 933738751
Tel: +34 934759600

Abstract

A new salt of ziprasidone with high aqueous solubility has been discovered as a result of a salt screening and it has been found to exist in three anhydrous polymorphic forms. One of these forms shows the highest aqueous solubility ever reported for ziprasidone salts in combination with a high kinetic stability, becoming a good candidate for further pharmaceutical development.

Graphical abstract: Ziprasidone malate, a new trimorphic salt with improved aqueous solubility

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Article information

DOI
https://doi.org/10.1039/B813401D
Article type
Paper
Submitted
01 Aug 2008
Accepted
05 Dec 2008
First published
21 Jan 2009

CrystEngComm, 2009,11, 791-795

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Ziprasidone malate, a new trimorphic salt with improved aqueous solubility

A. Portell, R. Barbas, M. Font-Bardia, P. Dalmases, R. Prohens and C. Puigjaner, CrystEngComm, 2009, 11, 791 DOI: 10.1039/B813401D

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