Issue 3, 2009
From the journal:

Organic & Biomolecular Chemistry

A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger

Jon C. Henrikson,a   Ashley R. Hoover,a   P. Matthew Joynera  and  Robert H. Cichewicz†*a  

* Corresponding authors

a Natural Products Discovery Group, Department of Chemistry and Biochemistry, 620 Parrington Oval, Room 208, University of Oklahoma, Norman, Oklahoma, USA
E-mail: rhcichewicz@ou.edu
Fax: +1 (405) 325-6111
Tel: +1 (405) 325-6969

Abstract

A new fungal metabolite, nygerone A (1), featuring a unique 1-phenylpyridin-4(1H)-one core that had previously not been reported from any natural source, has been obtained from Aspergillus niger using a chemical epigenetics methodology.

Graphical abstract: A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger

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Article information

DOI
https://doi.org/10.1039/B819208A
Article type
Communication
Submitted
29 Oct 2008
Accepted
01 Dec 2008
First published
11 Dec 2008

Org. Biomol. Chem., 2009,7, 435-438

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A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger

J. C. Henrikson, A. R. Hoover, P. M. Joyner and R. H. Cichewicz, Org. Biomol. Chem., 2009, 7, 435 DOI: 10.1039/B819208A

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