Issue 4, 2010
From the journal:

Chemical Communications

Cross-couplings between benzylic and aryl halides “on water”: synthesis of diarylmethanes†‡

Christophe Duplais,a   Arkady Krasovskiy,a   Alina Wattenberga  and  Bruce H. Lipshutz*a  

* Corresponding authors

a Department of Chemistry & Biochemistry, University of California, Santa Barbara, USA
E-mail: lipshutz@chem.ucsb.edu
Fax: +1 805 893 8265
Tel: +1 805 893 2521

Abstract

A remarkably simple entry to unsymmetrical diarylmethanes has been developed that relies on an in situ organozinc-mediated, palladium-catalyzed cross-coupling. Thus, by mixing a benzyl and aryl halide together in the presence of Zn metal and a Pd catalyst, diarylmethanes are formed at room temperature without assistance by a surfactant; hence, “on water”.

Graphical abstract: Cross-couplings between benzylic and aryl halides “on water”: synthesis of diarylmethanes

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Article information

DOI
https://doi.org/10.1039/B922280D
Article type
Communication
Submitted
26 Oct 2009
Accepted
30 Nov 2009
First published
09 Dec 2009

Chem. Commun., 2010,46, 562-564

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Cross-couplings between benzylic and aryl halides “on water”: synthesis of diarylmethanes

C. Duplais, A. Krasovskiy, A. Wattenberg and B. H. Lipshutz, Chem. Commun., 2010, 46, 562 DOI: 10.1039/B922280D

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