Issue 12, 2010
From the journal:

Chemical Communications

Novel epothilone lactones by an unusual diversion of the Grubbs'metathesis reaction†

Qiao-Hong Chen,a   Thota Ganesh,a   Yi Jiang,b   Abhijit Banerjee,c   Shubhada Sharma,c   Susan Bane,b   James P. Snyder*b  and  David G. I. Kingston*a  

* Corresponding authors

a Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, USA
E-mail: dkingston@vt.edu
Fax: +1 540 231 3255
Tel: +1 540 231 6570

b Department of Chemistry, Emory University, Atlanta, USA
E-mail: jsnyder@emory.edu

c Department of Chemistry, State University of New York of Binghamton, Binghamton, USA

Abstract

An unusual reaction with Grubbs' catalyst during the synthesis of bridged epothilones yielded five-membered internal lactones instead of the expected metathesis products. Three of the lactones have activities comparable to epothilone D.

Graphical abstract: Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B926174E
Article type
Communication
Submitted
11 Dec 2009
Accepted
21 Jan 2010
First published
09 Feb 2010

Chem. Commun., 2010,46, 2019-2021

Permissions

Request permissions

Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction

Q. Chen, T. Ganesh, Y. Jiang, A. Banerjee, S. Sharma, S. Bane, J. P. Snyder and D. G. I. Kingston, Chem. Commun., 2010, 46, 2019 DOI: 10.1039/B926174E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements