Issue 30, 2010
From the journal:

Chemical Communications

Discrimination of N6-methyl adenine in a specific DNA sequence†

Chikara Dohno,a   Tomonori Shibataa  and  Kazuhiko Nakatani*a  

* Corresponding authors

a The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki 567-0047, Japan
E-mail: nakatani@sanken.osaka-u.ac.jp
Fax: +81 6-6879-8459
Tel: +81 6-6879-8457

Abstract

We have developed a novel chemistry-based method to detect adenine methylation. A DNA probe functionalized with a formyl group discriminates between adenine and N6-methyl adenine by the formation of a selective interstrand cross-link.

Graphical abstract: Discrimination of N6-methyl adenine in a specific DNA sequence

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Article information

DOI
https://doi.org/10.1039/C0CC00172D
Article type
Communication
Submitted
01 Mar 2010
Accepted
26 Apr 2010
First published
11 May 2010

Chem. Commun., 2010,46, 5530-5532

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Discrimination of N6-methyl adenine in a specific DNA sequence

C. Dohno, T. Shibata and K. Nakatani, Chem. Commun., 2010, 46, 5530 DOI: 10.1039/C0CC00172D

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