Issue 32, 2010
From the journal:

Chemical Communications

An ultrahighly sensitive and selective electrochemical DNA sensor via nicking endonuclease assisted current change amplification†

Jinghua Chen,a   Jing Zhang,a   Juan Li,a   Fengfu Fu,a   Huang-Hao Yang*a  and  Guonan Chen*a  

* Corresponding authors

a Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China
E-mail: gnchen@fzu.edu.cn, hhyang@fzu.edu.cn
Fax: (+86)591-83713866

Abstract

Based on the “nicking endonuclease assisted” detection strategy, a novel electrochemical biosensor for the sequence-specific detection of DNA with ultrahigh sensitivity and selectivity is developed. By employing the above strategy, this DNA biosensor can detect as low as 0.068 fM target DNA and exhibits high discrimination ability even against a single-base mismatch.

Graphical abstract: An ultrahighly sensitive and selective electrochemical DNA sensor via nicking endonuclease assisted current change amplification

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Article information

DOI
https://doi.org/10.1039/C0CC00748J
Article type
Communication
Submitted
03 Apr 2010
Accepted
01 Jun 2010
First published
02 Jul 2010

Chem. Commun., 2010,46, 5939-5941

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An ultrahighly sensitive and selective electrochemical DNA sensor via nicking endonuclease assisted current change amplification

J. Chen, J. Zhang, J. Li, F. Fu, H. Yang and G. Chen, Chem. Commun., 2010, 46, 5939 DOI: 10.1039/C0CC00748J

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