Issue 30, 2010
From the journal:

Chemical Communications

Catalytic enantioselective synthesis of sterically demanding alcohols using di(2°-alkyl)zinc prepared by the refined Charette's method†

Manabu Hatano,a   Tomokazu Mizunoa  and  Kazuaki Ishihara*ab  

* Corresponding authors

a Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, Japan

b Japan Science and Technology Agency (JST), CREST, Furo-cho, Chikusa, Nagoya, Japan
E-mail: ishihara@cc.nagoya-u.ac.jp
Fax: +81-52-789-3331
Tel: +81-52-789-3222

Abstract

A highly practical, catalytic enantioselective 2°-alkyl addition to aldehydes and ketones was developed. Chiral phosphoramide ligand (1) with salt-free and solvent-free di(2°-alkyl)zinc reagents prepared from (2°-alkyl)MgCl was essential.

Graphical abstract: Catalytic enantioselective synthesis of sterically demanding alcohols using di(2°-alkyl)zinc prepared by the refined Charette's method

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Article information

DOI
https://doi.org/10.1039/C0CC01301C
Article type
Communication
Submitted
09 May 2010
Accepted
03 Jun 2010
First published
29 Jun 2010

Chem. Commun., 2010,46, 5443-5445

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Catalytic enantioselective synthesis of sterically demanding alcohols using di(2°-alkyl)zinc prepared by the refined Charette's method

M. Hatano, T. Mizuno and K. Ishihara, Chem. Commun., 2010, 46, 5443 DOI: 10.1039/C0CC01301C

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