Issue 43, 2010
From the journal:

Chemical Communications

Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins†

Omar Boutureira,a   François D'Hooge,a   Marta Fernández-González,a   Gonçalo J. L. Bernardes,a   Macarena Sánchez-Navarro,a   Julia R. Koeppea  and  Benjamin G. Davis*a  

* Corresponding authors

a Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK
E-mail: Ben.Davis@chem.ox.ac.uk
Fax: +44 (0)1865 285002
Tel: +44 (0)1865 275652

Abstract

A tag-and-modify strategy allows the practical synthesis of homogenous fluorinated glyco-amino acids, peptides and proteins carrying a fluorine label in the sugar and allows access to first examples of directly radiolabelled ([18F]-glyco)proteins.

Graphical abstract: Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins

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Article information

DOI
https://doi.org/10.1039/C0CC01576H
Article type
Communication
Submitted
25 May 2010
Accepted
02 Jul 2010
First published
16 Aug 2010

Chem. Commun., 2010,46, 8142-8144

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Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins

O. Boutureira, F. D'Hooge, M. Fernández-González, G. J. L. Bernardes, M. Sánchez-Navarro, J. R. Koeppe and B. G. Davis, Chem. Commun., 2010, 46, 8142 DOI: 10.1039/C0CC01576H

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