Issue 42, 2010
From the journal:

Chemical Communications

Fluorescent labeling of human mesenchymal stem cells by thiophene fluorophores conjugated to a lipophilic carrier†

Maria Duca,*a   Barbara Dozza,b   Enrico Lucarelli,b   Spartaco Santi,c   Audrey Di Giorgioa  and  Giovanna Barbarellad  

* Corresponding authors

a LCMBA UMR6001 CNRS Institut de Chimie de Nice, Université de Nice Sophia Antipolis, Parc Valrose, 06100 Nice, France
E-mail: maria.duca@unice.fr
Fax: +33 (0)492076151
Tel: +33 (0)492076153

b Rizzoli Orthopedic Inst., via di Barbiano 1/10, Bologna, Italy

c Istituto di Genetica Molecolare, CNR, Bologna, Italy

d ISOF-CNR and Mediteknology srl, Consiglio Nazionale Ricerche, Via P. Gobetti 101, 40129 Bologna, Italy

Abstract

Fluorescent labeling of human mesenchymal stem cells (hMSCs) is essential for their study in vitro and in vivo. Here, we report a new chemical biodelivery method for labeling hMSCs using a series of very efficient and highly versatile thiophene-based fluorescent dyes. Such conjugates contribute to a stable and viable labeling of hMSCs and constitute a promising strategy for in vivo applications.

Graphical abstract: Fluorescent labeling of human mesenchymal stem cells by thiophene fluorophores conjugated to a lipophilic carrier

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Article information

DOI
https://doi.org/10.1039/C0CC01918F
Article type
Communication
Submitted
16 Jun 2010
Accepted
06 Sep 2010
First published
22 Sep 2010

Chem. Commun., 2010,46, 7948-7950

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Fluorescent labeling of human mesenchymal stem cells by thiophene fluorophores conjugated to a lipophilic carrier

M. Duca, B. Dozza, E. Lucarelli, S. Santi, A. Di Giorgio and G. Barbarella, Chem. Commun., 2010, 46, 7948 DOI: 10.1039/C0CC01918F

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