Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe3O4 nanoparticle cores and a PEG-functionalized porous silica shell

Feng-Hua Chen; Li-Ming Zhang; Qing-Tao Chen; Yi Zhang; Zhi-Jun Zhang

doi:10.1039/C0CC02577A

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Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe₃O₄nanoparticle cores and a PEG-functionalized porous silica shell†

Feng-Hua Chen,^a Li-Ming Zhang,^a Qing-Tao Chen,^a Yi Zhang^a and Zhi-Jun Zhang*^a

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* Corresponding authors

^a Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Suzhou 215125, P. R. China
E-mail: zjzhang2007@sinano.ac.cn
Fax: 8651262603079
Tel: 8651262872556

Abstract

Coating a layer of PEG functionalized porous silica shell onto doxorubicin-conjugated Fe₃O₄ nanoparticles, we demonstrated, provides a number of combined advantages in view of the magnetic carrier's therapeutic functionality to treat tumors.

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Supplementary files

Experimental details of the synthesis and characterization of products PDF (653K)

Article information

DOI: https://doi.org/10.1039/C0CC02577A
Article type: Communication
Submitted: 15 Jul 2010
Accepted: 24 Sep 2010
First published: 12 Oct 2010

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Chem. Commun., 2010,46, 8633-8635

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Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe₃O₄ nanoparticle cores and a PEG-functionalized porous silica shell

F. Chen, L. Zhang, Q. Chen, Y. Zhang and Z. Zhang, Chem. Commun., 2010, 46, 8633 DOI: 10.1039/C0CC02577A

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