Issue 42, 2010

Profiling small molecule inhibitors against helix–receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Abstract

We validate a practical methodology for the rapid profiling of small molecule inhibitors of proteinprotein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

Graphical abstract: Profiling small molecule inhibitors against helix–receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Supplementary files

Article information

Article type
Communication
Submitted
02 Aug 2010
Accepted
21 Aug 2010
First published
20 Sep 2010

Chem. Commun., 2010,46, 8020-8022

Profiling small molecule inhibitors against helix–receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

J. R. Porter, M. R. Helmers, P. Wang, J. L. Furman, S. T. Joy, P. S. Arora and I. Ghosh, Chem. Commun., 2010, 46, 8020 DOI: 10.1039/C0CC02969F

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