Issue 43, 2010

Total chemical synthesis and X-ray structure of kaliotoxin by racemic proteincrystallography

Abstract

Here we report the total synthesis of kaliotoxin by ‘one pot’ native chemical ligation of three synthetic peptides. A racemic mixture of D- and L-kaliotoxin synthetic protein molecules gave crystals in the centrosymmetric space group P[1 with combining macron] that diffracted to atomic-resolution (0.95 Å), enabling the X-ray structure of kaliotoxin to be determined by direct methods.

Graphical abstract: Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography

Supplementary files

Article information

Article type
Communication
Submitted
10 Aug 2010
Accepted
06 Sep 2010
First published
28 Sep 2010

Chem. Commun., 2010,46, 8174-8176

Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography

B. L. Pentelute, K. Mandal, Z. P. Gates, M. R. Sawaya, T. O. Yeates and S. B. H. Kent, Chem. Commun., 2010, 46, 8174 DOI: 10.1039/C0CC03148H

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