Issue 43, 2010
From the journal:

Chemical Communications

β(1,3) Branched heptadeca- and linear hexadeca-saccharides possessing an aminoalkyl group as a strong ligand to dectin-1†

Hiroshi Tanaka,*a   Tetsuya Kawai,a   Yoshiyuki Adachi,b   Naohito Ohnob  and  Takashi Takahashi*a  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1-H-101 Ookayama, Meguro, Tokyo, Japan
E-mail: thiroshi@apc.titech.ac.jp
Fax: +81 3-5734-2884
Tel: +81 3-5734-2471

b Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi Hachioji, Tokyo, Japan
E-mail: ohnonao@ps.toyaku.ac.jp
Fax: +81 42-676-5570

Abstract

In this report, we describe the convergent synthesis of β(1,3) oligosaccharides containing an aminoalkyl group. The branched heptadecasaccharide and linear hexadecasaccharide acted as ligands of dectin-1 whose binding affinity was only 10-fold weaker than that of natural SPG and exhibited dectin-1 agonist activity.

Graphical abstract: β(1,3) Branched heptadeca- and linear hexadeca-saccharides possessing an aminoalkyl group as a strong ligand to dectin-1

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Article information

DOI
https://doi.org/10.1039/C0CC03153D
Article type
Communication
Submitted
10 Aug 2010
Accepted
14 Sep 2010
First published
01 Oct 2010

Chem. Commun., 2010,46, 8249-8251

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β(1,3) Branched heptadeca- and linear hexadeca-saccharides possessing an aminoalkyl group as a strong ligand to dectin-1

H. Tanaka, T. Kawai, Y. Adachi, N. Ohno and T. Takahashi, Chem. Commun., 2010, 46, 8249 DOI: 10.1039/C0CC03153D

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