Issue 8, 2010
From the journal:

Nanoscale

Opening of DNA double helix at room temperature: Application of α-cyclodextrin self-aggregates†

Syed S. Jaffer,a   Prasun Ghosh,a   Anindita Dasb  and  Pradipta Purkayastha*a  

* Corresponding authors

a Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, WB, India
E-mail: ppurkayastha@iiserkol.ac.in

b Department of Biological Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, WB, India

Abstract

Self-aggregation of α-cyclodextrin (α-CD) can induce DNA opening at room temperature (25 °C) owing to the hydroxyl groups on the surface of the spherical aggregates of α-CD, which promote hydrogen bonding with the flipped-out bases in DNA duplex prohibiting them from reverting back.

Graphical abstract: Opening of DNA double helix at room temperature: Application of α-cyclodextrin self-aggregates

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Article information

DOI
https://doi.org/10.1039/C0NR00184H
Article type
Communication
Submitted
10 Mar 2010
Accepted
30 Apr 2010
First published
04 Jun 2010

Nanoscale, 2010,2, 1420-1422

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Opening of DNA double helix at room temperature: Application of α-cyclodextrin self-aggregates

S. S. Jaffer, P. Ghosh, A. Das and P. Purkayastha, Nanoscale, 2010, 2, 1420 DOI: 10.1039/C0NR00184H

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