Issue 22, 2010

Investigating possible changes in protein structure during dendrimer–protein binding

Abstract

Building on our previous results that revealed a sized based mechanism for dendrimer/protein binding, the mechanism of complexation is further probed using CD spectroscopy; the results demonstrate that dendrimer/protein binding is not accompanied by changes in the protein's structure and that binding takes place on the interfacial area/active site entrance.

Graphical abstract: Investigating possible changes in protein structure during dendrimer–protein binding

Supplementary files

Article information

Article type
Communication
Submitted
23 Apr 2010
Accepted
02 Aug 2010
First published
23 Sep 2010

Org. Biomol. Chem., 2010,8, 5056-5058

Investigating possible changes in protein structure during dendrimerprotein binding

F. Chiba, G. Mann and L. J. Twyman, Org. Biomol. Chem., 2010, 8, 5056 DOI: 10.1039/C0OB00041H

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