Unified synthesis of enantiopure β2h, β3h and β2,3-amino acids

Abstract

One for all, all for one! A single chiral auxiliary and synthetic route can be used for a three-step (cycloaddition, auxiliary removal and fragmentation) preparation of enantiopure β³h, β²h and β^2,3-amino acids (>99% ee). This approach works for a wide variety of both natural and unnatural side chains, provides access to either enantiomeric form, and can be executed on a preparative scale without recourse to column chromatography.