Issue 10, 2011
From the journal:

Chemical Communications

Rapid, quantitative, and site specific synthesis of biomolecular radicals from a simple photocaged precursor†

Tony Ly,ab   Xing Zhang,a   Qingyu Sun,a   Benjamin Moore,a   Yuanqi Taoa  and  Ryan R. Julian*a  

* Corresponding authors

a Department of Chemistry, University of California, Riverside, Riverside, CA, USA
E-mail: ryan.julian@ucr.edu

b Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee, UK
E-mail: tly@dundee.ac.uk

Abstract

Novel p-iodobenzoate-based labelling reagents are shown to be effective photocaged precursors for synthesizing biomolecular radicals site-selectively in the gaseous and condensed phases. In vacuo, a single pulse of UV photons (266 nm) is sufficient to quantitatively photolyse the C–I bond. In aqueous solutions, the photolysis half-life is estimated to be 2.5 minutes when irradiating with a 15 W compact fluorescent lamp (254 nm).

Graphical abstract: Rapid, quantitative, and site specific synthesis of biomolecular radicals from a simple photocaged precursor

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Article information

DOI
https://doi.org/10.1039/C0CC03363D
Article type
Communication
Submitted
19 Aug 2010
Accepted
04 Jan 2011
First published
24 Jan 2011

Chem. Commun., 2011,47, 2835-2837

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Rapid, quantitative, and site specific synthesis of biomolecular radicals from a simple photocaged precursor

T. Ly, X. Zhang, Q. Sun, B. Moore, Y. Tao and R. R. Julian, Chem. Commun., 2011, 47, 2835 DOI: 10.1039/C0CC03363D

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