Issue 3, 2011

Methionineligand selectively promotes monofunctional adducts between trans-EE platinum anticancer drug and guanine DNA base

Abstract

A detailed study on the reaction mechanism of trans-EE and trans-EE/Met Pt-containing anticancer drugs was carried out in order to rationalize the experimental kinetic data concerning the whole process leading to DNA platination.

Graphical abstract: Methionine ligand selectively promotes monofunctional adducts between trans-EE platinum anticancer drug and guanine DNA base

Supplementary files

Article information

Article type
Communication
Submitted
01 Sep 2010
Accepted
20 Oct 2010
First published
11 Nov 2010

Chem. Commun., 2011,47, 887-889

Methionine ligand selectively promotes monofunctional adducts between trans-EE platinum anticancer drug and guanine DNA base

M. E. Alberto and N. Russo, Chem. Commun., 2011, 47, 887 DOI: 10.1039/C0CC03605F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements