A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action†
Abstract
Clostridium
botulinum produces the most lethal
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* Corresponding authors
a
Departments of Chemistry, Immunology and Microbial Science, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, USA
E-mail:
kdjanda@scripps.edu
Fax: +1 858 784-2595
Tel: +1 858 784-2516
b Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, USA
c Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, USA
d Discovery Biology, Takeda San Diego, Inc., 10410 Science Center Drive, San Diego, USA
Clostridium
botulinum produces the most lethal
N. T. Salzameda, L. M. Eubanks, J. S. Zakhari, K. Tsuchikama, N. J. DeNunzio, K. N. Allen, M. S. Hixon and K. D. Janda, Chem. Commun., 2011, 47, 1713 DOI: 10.1039/C0CC04078A
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