Issue 9, 2011

The tightly regulated copper window in yeast

Abstract

The two opposing yeast copper regulators, Ace1 and Mac1, were converted into two fluorescent probes, Ace1-FRET and Mac1-FRET, which selectively and sensitively respond to Cu+. The Cu+-binding curves obtained for both regulators as well as for the copper storage proteins Cup1 and Crs5 show that free copper(I) is maintained in a narrow window inside yeast.

Graphical abstract: The tightly regulated copper window in yeast

Supplementary files

Article information

Article type
Communication
Submitted
08 Oct 2010
Accepted
07 Dec 2010
First published
21 Dec 2010

Chem. Commun., 2011,47, 2571-2573

The tightly regulated copper window in yeast

S. V. Wegner, F. Sun, N. Hernandez and C. He, Chem. Commun., 2011, 47, 2571 DOI: 10.1039/C0CC04292G

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