Issue 10, 2011
From the journal:

Chemical Communications

Ultrasensitive scanometric strategy for detection of matrix metalloproteinases using a histidine tagged peptide–Au nanoparticle probe†

Wei Cheng,ab   Yunlong Chen,a   Feng Yan,c   Lin Ding,a   Shijia Ding,b   Huangxian Ju*ab  and  Yibing Yin*b  

* Corresponding authors

a Key Laboratory of Analytical Chemistry for Life Science (Ministry of Education of China), Department of Chemistry, Nanjing University, Nanjing 210093, P.R. China
E-mail: hxju@nju.edu.cn
Fax: +86 25 83593593
Tel: +86 25 83593593

b Key Laboratory of Laboratory Medical Diagnostics (Ministry of Education of China), Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China

c Jiangsu Institute of Cancer Prevention and Cure, Nanjing 210009, P.R. China

Abstract

A simple scanometric strategy was developed for ultrasensitive assay of matrix metalloproteinases based on their discriminatory and proteolytic activity by integrating a newly designed peptide–gold nanoparticle probe, a nitrilotriacetic acid modified chip and silver signal amplification.

Graphical abstract: Ultrasensitive scanometric strategy for detection of matrix metalloproteinases using a histidine tagged peptide–Au nanoparticle probe

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Article information

DOI
https://doi.org/10.1039/C0CC04441E
Article type
Communication
Submitted
15 Oct 2010
Accepted
10 Dec 2010
First published
18 Jan 2011

Chem. Commun., 2011,47, 2877-2879

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Ultrasensitive scanometric strategy for detection of matrix metalloproteinases using a histidine tagged peptide–Au nanoparticle probe

W. Cheng, Y. Chen, F. Yan, L. Ding, S. Ding, H. Ju and Y. Yin, Chem. Commun., 2011, 47, 2877 DOI: 10.1039/C0CC04441E

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