Issue 13, 2011
From the journal:

Chemical Communications

Single-walled carbon nanotubes chemiresistor aptasensors for small molecules: picomolar level detection of adenosine triphosphate†

Basanta K. Das,‡a   Chaker Tlili,‡a   Sushmee Badhulika,b   Lakshmi N. Cella,c   Wilfred Chena  and  Ashok Mulchandani*a  

* Corresponding authors

a Chemical and Environmental Engineering Department, University of California, Riverside, USA
E-mail: adani@engr.ucr.edu
Fax: +1 951-827-5696
Tel: +1 951-827-6419

b Electrical Engineering Department, University of California, Riverside, USA

c Cell, Molecular and Developmental Biology Graduate Program, University of California, Riverside, USA

Abstract

Here we report single walled-carbon nanotubes (SWNTs)-based chemiresistor aptasensors for highly sensitive and selective detection of weakly or uncharged molecules using the displacement format. As a proof-of-concept we demonstrate the detection of ATP, a small weakly charged molecule, by displacement of the ssDNA anti-ATP aptamer hybridized to a small capture oligonucleotide covalently attached on SWNTs, with picomolar sensitivity and selectivity over GTP.

Graphical abstract: Single-walled carbon nanotubes chemiresistor aptasensors for small molecules: picomolar level detection of adenosine triphosphate

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Article information

DOI
https://doi.org/10.1039/C0CC04733C
Article type
Communication
Submitted
01 Nov 2010
Accepted
14 Jan 2011
First published
02 Feb 2011

Chem. Commun., 2011,47, 3793-3795

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Single-walled carbon nanotubes chemiresistor aptasensors for small molecules: picomolar level detection of adenosine triphosphate

B. K. Das, C. Tlili, S. Badhulika, L. N. Cella, W. Chen and A. Mulchandani, Chem. Commun., 2011, 47, 3793 DOI: 10.1039/C0CC04733C

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